Berlin Cures strengthens Business Advisory Board with the appointments of Ulf Berg, Ph.D., and Dragan Grabulovski, Ph.D.
Pubblicato il: 27/06/2018 08:00
ZUG, Switzerland, June 27, 2018 /PRNewswire/ -- Drug developer Berlin Cures today announced the formation of a Business Advisory Board (BAB) and the appointment of its first two members, Dr. Ulf Berg and Dr. Dragan Grabulovski. The BAB's role will be to provide ongoing counsel, along with strategic guidance in business development decision-making, as the company advances the clinical development of its pipeline. The company's lead drug candidate, BC 007, is the first drug designed to target an autoimmune cause of heart failure as well as the symptoms of the disease.
"Drs. Berg and Grabulovski each bring rich, valuable skills and insights to Berlin Cures," said Dr. Johannes Müller, founder, president of the Board of Directors of Berlin Cures Holding AG. "Their counsel will allow for better market understanding of the unmet medical need serviced by our revolutionary therapy, BC 007. Our entire leadership team looks forward to working closely with them as we shape and execute on our corporate strategy."
Dr. Berg commented, "The skills of the team in place and the focus of the business will provide unique value to the patients and stakeholders, alike. There is great potential for BC 007 for the treatment of dilated cardiomyopathy as well as in other medical conditions."
Dr. Grabulovski added, "Berlin Cures has the potential to treat the underlying cause of cardiac insufficiency rather than just the symptoms. It will be imperative for us to properly position the company and its pipeline to maximize the benefits that this groundbreaking therapy."
BC 007 is a DNA aptamer-based compound that binds to and eliminates pathogenic autoantibodies directed against the beta-1 adrenoceptor, a receptor belonging to the large family of cell surface receptors known as G-protein coupled receptors that regulate the heart's rate and contraction strength. Heart cells are harmed by autoantibodies that chronically bind to these receptors in a process that has been found to lead to heart cell death and organ failure in 80 percent of dilated cardiomyopathy patients. BC 007 is currently completing a Phase 1 clinical study for the treatment of cardiomyopathy (NCT02955420).
About Berlin CuresBerlin Cures Holding AG, a privately-held company founded late in 2014 and based in Zug, Switzerland, is building a new generation of treatments based on a quarter of a century of research on autoimmune diseases conducted at the renowned Charité Berlin and at the Max-Delbrueck-Center in Berlin. The focus is to develop treatments for diseases with autoimmune pathology in which functional autoantibodies directed against G-protein-coupled receptors of different types are present.
With over 1000 different sub-types, the family of G-protein-receptors constitutes the largest protein super-family with the physiological ability to sense molecules outside the cell. Berlin Cures holds the IP for a platform of aptamers that bind to and neutralize these functional autoantibodies, which play an important role in the pathophysiology of several autoimmune-diseases.
Recent studies involving heart failure, pulmonary hypertension, chronic fatigue syndrome, pre-eclampsia and a significant number of other diseases have shown that these functional autoantibodies play a highly underestimated role in disease development and sustenance. Neutralizing these autoantibodies can lead to substantial improvements in treatment.
For more information, http://www.berlincures.ch.
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