The deadly dispute between Israel and Gaza's Islamist rulers Hamas and the fragile truce agreed between the two sides last month is on the agenda Monday at a meeting in Rome of the Global Coalition against ISIS.
"The conflict between Israel and Hamas risks igniting flashpoints in the entire region," foreign minister Luigi Di Maio told a geopolitics conference focused on the Middle East.
There have been reports of rockets being fired against Israel from southern Lebanon as well as from Gaza, Di Maio noted.
"In this violent context, jihadist groups and criminal organisations boost their power and a multi-polar situation emerges which terrorist organisations manage to penetrate," Di Maio went on.
"We will discuss this face to face at Monday's Global Coalition against ISIS meeting, attended by 73 ministers representing most countries leading the fight against terrorism", Di Maio said.
Di Maio will co-chair Monday's meeting with US counterpart Antony Blinken, according to a State Department statement.
While in Rome, Blinken will also have bilateral meetings with Di Maio and with Italy's president Sergio Mattarella "to underscore the US-Italy partnership’s important role in addressing key global priorities," the statement said.